Vitex (Vitex agnus-castus)

Evidence-based guide to Vitex: benefits, dosage, safety and interactions.

Evidence

Moderate: Multiple RCTs and a 2017 meta-analysis show consistent benefit for PMS; EMA-registered. Trial quality is mixed and standardization varies across products.

Traditional use and mechanism

PMS relief; menstrual cycle regulation; luteal phase support; breast tenderness. Used in classical Greek medicine (Hippocrates, Dioscorides) through modern European phytomedicine. EMA registered monograph.

Safety

Well-tolerated in clinical trials (Ze 440 preparation). Most common side effects: mild nausea, headache, acne flare, initial cycle-length change in first 1–2 cycles (normalises with continued use). EMA positive monograph for PMS (well-established use for Ze 440; traditional use for other preparations).